This guide is a reference document for technical personnel, program managers, warehouse managers and service providers on how to carry out and estimate total commodity needs at the national and regional level. The guide provides a general step-by-step approach for conducting a quantification exercise at the national level and includes specific guidance on how to use the quantification results to: (1) Identify funding needs and gaps for the procurement of the required drugs and inputs; (2) Coordinate procurement and delivery times to ensure a continuous and effective delivery of commodities.